The Microbiologist
  • Home - The Microbiologist Project
  • What Are Viruses?
    • Viruses - Living or Not?
    • Structures of Viruses
    • Cycles of Viruses
    • Viral Infections in Humans - Polio
    • Viral Infections in Humans - West Nile Virus
    • Viral Defence System
  • What Are Bacteria?
    • Bacterial Growth & Reproduction
    • Phases of Growth
    • Metabolism and Respiration
    • Groups of Bacteria
    • Helpful Bacteria?
    • Bacterial Infections in Humans
  • Bibliography

Cycles of Viruses

Viruses undergo cycles of replication once they have infected a host cell. There are two types of replication, the lytic and lysogenic cylces.  Although they are different, viral replication can involve both methods in separate phases or interchange between the two under certain environmental pressures.  
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Lytic is the main cycle in viral replication, with five key stages as outlined:
1. Virus attaches to the host cell receptors.

2. Viral DNA or RNA is injected into the cell.
3. Biosynthesis occurs as host cell's genes are destroyed and replaced with the virus', taking over metabolic activities.
4. Viral DNA and capsids are produced and assembled.
5.  Once hundreds of new virus fill up the cell and cause it burst open, viruses are released.

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Lysogenic cycles occur in viruses such as Herpes, Hepatitus and HIV as outlined:
1. Virus attaches to the host cell receptors.
2. Viral DNA or RNA is injected into the cell.
3. Viral DNA becomes part of cell DNA chromosome and is dormant (does not replicate); cell maintains normal activity.
4. When the host cell DNA chromosome replicates during cell division, the passive and dormant viral DNA also replicates.

To contrast, in the lytic cycle viral DNA destroys cell DNA, takes over cell functions and destroys the cell; in lysogenic cycle, viral DNA merges with cell DNA and does not destroy the cell. 
In lytic cycle, the virus replicates and produces progenies; in lysogenic cycle the virus does not produce progeny.
In lytic cycle, there are viral symptoms as a result of infection; in lysogenic cycle there are no viral symptoms.
In lytic cycle, virulent viral infection occurs; in lysogenic cycle, only temperate viral replication takes place through cell division. 
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